Herbicide glyphosate efficiently inhibits growth of pathogenic <i>Prototheca</i> algae species, suggesting the presence of novel pathways for the development of anti-algal drugs.

ABSTRACT: Prototheca are ubiquitous algae and occasional pathogens of humans and animals. While rare, the infection is often fatal and treatment options are limited to antifungals with low efficiency. Here, using growth curve assays, we demonstrate that five pathogenic species of Prototheca (P. blaschkeae, P. wickerhamii, P. cutis, P. ciferrii, P. bovis) were fully inhibited by 50-100 μg/mL of herbicide glyphosate, suggesting novel pathways that can be considered for anti-algal drug development.IMPORTANCEPrototheca are algae frequently found in the environment that occasionally cause infections in humans and animals. Although these infections are rare, they are often deadly for immunocompromised patients. Considering the rising ambient temperatures that promote algal bloo

SUBMITTER: Makarova O 

PROVIDER: S-EPMC11878087 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature