Interspecies signaling modulates the biosynthesis of antimicrobial secondary metabolites related to biological control activities of <i>Pseudomonas fluorescens</i> 2P24.

ABSTRACT: Signaling between rhizosphere microorganisms is crucial in bacteria interaction and communication, shaping the rhizomicrobiome. Plant growth-promoting bacterium Pseudomonas produces a spectrum of important antibiotics to inhibit plant pathogens, albeit with an associated metabolic burden. Antibiotics could function as intra- and interspecies signals at subinhibitory concentrations to coordinate gene expression and microbial behaviors. In this work, we characterized pyoluteorin as an interspecies signal that modulates the biosynthesis of 2,4-diacetylphloroglucinol (2,4-DAPG), a broad-spectrum biocontrol agent, in non-pyoluteorin-producing Pseudomonas fluorescens 2P24. We demonstrated that the key transcriptional repressor PhlF from the 2,4-DAPG biosynthetic gene cluster sponta

SUBMITTER: Zhang N 

PROVIDER: S-EPMC11878095 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature