Pre-treatment amino acids and risk of paclitaxel-induced peripheral neuropathy in SWOG S0221.

ABSTRACT:

Background

Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting and debilitating neurotoxicity of many commonly used anti-cancer agents, including paclitaxel. The objective of this study was to confirm the previously found inverse association between pre-treatment blood concentrations of histidine and CIPN occurrence and examine relationships of other amino acids with CIPN severity.

Methods

Pre-treatment serum concentrations of 20 amino acids were measured in the SWOG S0221 (NCT00070564) trial of patients with early-stage breast cancer receiving paclitaxel. The associations between amino acids and CIPN severity were tested in regression analysis adjusted for paclitaxel schedule, age, self-reported race, and body mass index with Bonferroni correction. The

SUBMITTER: Chen CS 

PROVIDER: S-EPMC11878155 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature