Excessive bile acids level predisposes to adverse perinatal outcomes in women with abnormal pre-pregnancy body mass index.

ABSTRACT:

Background

Both low/high pre-pregnancy body mass index (BMI) and increased bile acid levels during pregnancy (known as gestational hypercholanemia) were risk factors for adverse pregnancy outcomes, with limited information on their joint effects.

Methods

A total of 63,066 pregnant women were involved in a large retrospective cohort study from May 2014 to December 2018 in Shanghai, China. Data of pregnancy outcomes including hypercholanemia, hypertensive disorders in pregnancy (HDP), preterm delivery, and small for gestation age (SGA), were obtained for multivariable logistic analysis.

Results

Pre-pregnancy BMI was negatively associated with serum total bile acid (TBA) concentrations during gestation and the risk of hypercholanemia (p < 0.001). Low pre-pregnancy

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC11878157 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature