Disruption in Autonomic Nervous Activity Is Associated With Central and Peripheral-Level in Dry Eye With Unstable Tear Film.

ABSTRACT:

Purpose

To measure autonomic nerve activity (ANA) in several eye conditions and verify whether ANA modulation is regulated by peripheral or central control in short tear film break-up time dry eye (sBUTDE).

Methods

This study included 23 eyes of 23 patients with sBUTDE (mean age 55.2 ± 16.1 years; range 21-88 years) and 24 eyes of 24 age-matched non-dry eye (DE) controls. An ANA measurement, personality questionnaire, and Ocular Surface Disease Index were administered. ANA was continuously measured for 10 minutes under three conditions: eyes closed, eyes open, and eyes open under ocular surface anesthesia.

Results

The low-frequency (LF)/high-frequency (HF) ratio (LF/HF) with eyes closed was significantly higher in the sBUTDE group than in the control group (P < 0.05).

SUBMITTER: Kaido M 

PROVIDER: S-EPMC11878196 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature