α/β Hydrolases: Toward Unraveling Entangled Classification.

ABSTRACT: α/β Hydrolase-like enzymes form a large and functionally diverse superfamily of proteins. Despite retaining a conserved structural core consisting of an eight-stranded, central β-sheet flanked with six α-helices, they display a modular architecture allowing them to perform a variety of functions, like esterases, lipases, peptidases, epoxidases, lyases, and others. At the same time, many α/β hydrolase-like families, even enzymatically distinct, share a high degree of sequence similarity. This imposes several problems for their annotation and classification, because available definitions of particular α/β hydrolase-like families overlap significantly, so the unambiguous functional assignment of these superfamily members remains a challenging task. For instance, two large and important peptid

SUBMITTER: Ozhelvaci F 

PROVIDER: S-EPMC11878206 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature