Using pupillometry to predict outcome in cognitive behavioral therapy for negative symptoms of schizophrenia.

ABSTRACT:

Background

Clinical trials of cognitive-behavioral therapy (CBT) for negative symptoms of schizophrenia have provided mixed results, perhaps because some patients are more likely to benefit than others. Patients likely to benefit may be those with greater pre-treatment motivation. To better examine the effects of motivation on treatment outcome, more objective measures of motivation are needed. Pupillary responses provide an objective biomarker of cognitive effort and motivation, with greater dilation associated with greater effort and motivation.

Aims

The current study examined whether pre-treatment baseline pupil dilation predicted motivation and pleasure (MAP) negative symptom reduction in an open clinical trial of CBT for individuals with schizophrenia.

Methods

Pu

SUBMITTER: Delay C 

PROVIDER: S-EPMC11878216 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature