Risk associated circulating biomarkers S100A3 identified in congenital heart disease-associated pulmonary arterial hypertension.

ABSTRACT: With improved survival rates among congenital heart disease (CHD) patients, pulmonary arterial hypertension (PAH) linked to CHD becomes more prevalent in both children and adults. PAH remains a significant contributor to morbidity and mortality in this population. Although genome-wide association studies (GWAS) have identified potential genetic variants with PAH risk and prognosis, the identification of circulating biomarkers with causal roles in CHD-PAH remains unclear. We employed the summary data-based Mendelian randomization (SMR) method, integrating expression profile data from the Gene Expression Omnibus (GEO) database related to CHD-PAH. This approach aimed to pinpoint genes causally associated with risk of CHD-PAH. We used a two-sample Mendelian randomization (MR) approach to effic

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11878227 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature