Photocatalytic 1,3-difluoroalkylcarboxylation of alkenes by triple kinetic-controlled radical self-ordering.

ABSTRACT: A transition-metal-free protocol for the unsymmetrical radical 1,3-difunctionalization of alkenes has been established for the first time in the form of 1,3-difluoroalkylcarboxylation by a photocatalytic radical three-component reaction of allyl formates, trifluoroacetanilides, and cesium formate. This reaction employs formate as the carboxylating reagent and trifluoroacetanilide as the difluoroalkylating reagent via C-F bond activation. As a result, a series of previously inaccessible unsymmetrical difluorinated adipic acid derivatives can be easily and efficient prepared. Mechanism studies reveal that triple kinetic-controlled radical self-ordering is the key to this unique reaction. This radical sorting involves the fast initiation of a CO₂ radical anion and its chemos

SUBMITTER: Fu H 

PROVIDER: S-EPMC11878238 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature