Ionic Strength-Induced Compartmentalization for Nanogel-in-Microgel Colloids.

ABSTRACT: Compartmentalization is crucial for control over complex biological cascade reactions. In microgels, the formation of discrete compartments allows for simultaneous uptake and orthogonal release of physicochemically distinct drugs, among others. However, many state-of-the-art approaches yielding compartmentalized microgels require the use of specific, though not always biocompatible, components and temperatures well above the physiological range, which may damage possible biological cargo. Therefore, a novel technique to fabricate compartmentalized microgels by exploiting ionic strength-induced precipitation as a mechanism for compartmentalization is developed. For this, a droplet-based microfluidic approach in which preformed nanogels are incorporated into poly(N-isopropylacrylamide)- or p

SUBMITTER: Pieper MI 

PROVIDER: S-EPMC11878252 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature