Coaxial Helices in Chiral Supramolecular Aggregates from Highly Hindered Chiral Allenes.

ABSTRACT: Chiral allenes self-assembly following a cooperative mechanism into a supramolecular chiral aggregate consisting of two coaxial helices: the internal helix described by the allene stack and the external helix which consist in a 4-helix described by the four allene substituents. More precisely, this supramolecular aggregate possesses six axially chiral elements within its structure-the allene, the allene stack (internal helix) and the stacks of the four allene substituents (external 4-helix)-. Interestingly, slight variations in the magnitude of the tilting degree while keeping its P- or M- orientation (internal helix) can vary the orientation of the 4-axial motifs at the external helix. Thus, while (P)-1 produces a supramolecular helix with a Θ ca. 15° (P_int) and a M₁

SUBMITTER: Lago-Silva M 

PROVIDER: S-EPMC11878346 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature