Impact of frailty status on the effect of a multidomain lifestyle intervention on cognition.

ABSTRACT:

Background

Frailty often precedes and co-occurs with dementia. A multidomain lifestyle intervention has shown favourable effects on cognition. We aimed to investigate if frailty status modifies this intervention effect.

Methods

The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) recruited 1259 participants aged 60-77 years who were at risk of dementia. They were randomised to receive a multidomain intervention (diet, exercise, cognitive training and vascular risk monitoring) or regular health advice for two years. The outcome was a change in cognition (neuropsychological test battery composite score). Frailty and prefrailty were defined according to the Fried phenotype. Mixed models were used to investigate if frailty status at ba

SUBMITTER: Poyhonen J 

PROVIDER: S-EPMC11878527 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature