Cell-based therapies in preclinical models of necrotizing enterocolitis: a systematic review and meta-analysis.

ABSTRACT: Necrotizing enterocolitis (NEC) remains an incurable gut complication of prematurity with significant morbidity and mortality. Cell therapies, including mesenchymal stromal cells (MSCs), may be a promising treatment given their anti-inflammatory and regenerative potential. We assessed the effect of MSCs and other cell therapies (not classified as MSCs) on incidence, severity, and mortality in preclinical models of NEC. Bibliographic and gray literature searches yielded 17 371 records with 107 full-text articles assessed and ultimately 16 studies were included. These studies featured only rodents NEC models via combination of hyperosmolar feeds, hypoxia, hypothermia, or lipopolysaccharides. Ten studies used interventions with MSCs. Only 2 met the minimal criteria to define MSCs proposed by

SUBMITTER: Maltais-Bilodeau C 

PROVIDER: S-EPMC11878585 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature