Resuscitation in Paediatric Septic Shock Using Vitamin C and Hydrocortisone (RESPOND): The RESPOND Randomized Controlled Trial Protocol.

ABSTRACT:

Objectives

Pediatric sepsis results in significant morbidity and mortality worldwide. There is an urgent need to investigate adjunctive therapies that can be administered early. We hypothesize that using vitamin C combined with hydrocortisone increases survival free of inotropes/vasopressors support until day 7 compared with standard care. Here we describe the Resuscitation in Paediatric Septic Shock using Vitamin C and Hydrocortisone (RESPOND) trial protocol, which aims to address this hypothesis.

Design

Randomized, open label, controlled, parallel-group, three-arm trial with integrated economic evaluation.

Setting

Nine Australia and New Zealand PICUs, with interest from additional international sites.

Patients

Children between 7 days and younger than 18 years

SUBMITTER: Raman S 

PROVIDER: S-EPMC11878590 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature