EasyEWAS: a flexible and user-friendly R package for epigenome-wide association study.

ABSTRACT:

Motivation

Rapid advancements in high-throughput sequencing technologies especially the Illumina DNA methylation Beadchip greatly fuelled the surge in epigenome-wide association study (EWAS), providing crucial insights into intrinsic DNA methylation modifications associated with environmental exposure, diseases, and health traits. However, current tools are complex and less user-friendly to accommodate appropriate EWAS designs and make downstream analyses and result interpretations complicated, especially for clinicians and public health professionals with limited bioinformatic skills.

Results

We integrated the current state-of-the-art EWAS analysis methods and tools to develop a flexible and user-friendly R package easyEWAS for conducting DNA methylation-based research usin

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11878637 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature