Air pollution from biomass burning disrupts early adolescent cortical microarchitecture development.

ABSTRACT: Exposure to outdoor particulate matter (PM_2.5) represents a ubiquitous threat to human health, and particularly the neurotoxic effects of PM_2.5 from multiple sources may disrupt neurodevelopment. Studies addressing neurodevelopmental implications of PM exposure have been limited by small, geographically limited samples and largely focus either on macroscale cortical morphology or postmortem histological staining and total PM mass. Here, we leverage residentially assigned exposure to six, data-driven sources of PM_2.5 and neuroimaging data from the longitudinal Adolescent Brain Cognitive Development Study (ABCD Study®), collected from 21 different recruitment sites across the United States. To contribute an interpretable and actionable assessment of the role

SUBMITTER: Bottenhorn KL 

PROVIDER: S-EPMC11878718 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature