In vivo bioengineered tooth formation using decellularized tooth bud extracellular matrix scaffolds.

ABSTRACT: The use of dental implants to replace lost or damaged teeth has become increasingly widespread due to their reported high survival and success rates. In reality, the long-term survival of dental implants remains a health concern, based on their short-term predicted survival of ~15 years, significant potential for jawbone resorption, and risk of peri-implantitis. The ability to create functional bioengineered teeth, composed of living tissues with properties similar to those of natural teeth, would be a significant improvement over currently used synthetic titanium implants. To address this possibility, our research has focused on creating biological tooth substitutes. The study presented here validates a potentially clinically relevant bioengineered tooth replacement therapy for eventual u

SUBMITTER: Zhang W 

PROVIDER: S-EPMC11878782 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature