Paternal age and neonatal outcomes: a population-based cohort study.

ABSTRACT:

Study question

Is paternal age associated with neonatal outcomes?

Summary answer

Paternal age is independently associated with preterm birth (PTB) and caesarean section.

What is known already

Advanced maternal age has long been recognized as a major risk factor for adverse neonatal outcomes. However, the association between paternal age and neonatal outcomes are not well established, yet it is biologically plausible that an increasing number of genetic and epigenetic sperm abnormalities in older males may contribute to adverse neonatal outcomes.

Study design size duration

This population-based cohort study was based on the National Free Preconception Checkups Project between 1 January 2014 and 31 December 2019 in Guangdong Province, China. Paternal age at the m

SUBMITTER: Xiong W 

PROVIDER: S-EPMC11878789 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature