Inflammatory stimuli and hypoxia on atherosclerotic plaque thrombogenicity: Linking macrophage tissue factor and glycolysis.

ABSTRACT:

Background

The thrombogenic potential of cells within atherosclerotic plaques is critical in the formation of a coronary thrombus. We hypothesized that a combination of inflammatory and hypoxic stimuli enhances tissue factor (TF) expression and glycolysis in cells in atherosclerotic plaques and contributes to coronary thrombus formation.

Aims

To identify TF- and hexokinase (HK)-II-expressing cells in coronary atherosclerotic plaques and thrombi and determine the effects of combined inflammatory and hypoxic stimuli and glycolysis on TF expression in peripheral blood mononuclear cell-derived macrophages.

Methods

We immunohistochemically assessed TF and HK-II expression in stable (n =  20) and unstable (n =  24) human coronary plaques and aspirated acute coronary thrombi

SUBMITTER: Maekawa K 

PROVIDER: S-EPMC11878908 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature