β-Trace Protein as a Potential Biomarker for CSF-Venous Fistulas.

ABSTRACT:

Background and purpose

Accurately identifying patients with CSF-venous fistulas (CVF) causing spontaneous intracranial hypotension, is a diagnostic dilemma. This conundrum underscores the need for a CVF biomarker to help select who should undergo an invasive myelogram for further diagnostic work-up. β-trace protein (BTP) is the most abundant CNS-derived protein in the CSF and, therefore, is a potential venous biomarker for CVF detection. The purpose of our study was to measure venous BTP levels as a potential CVF biomarker.

Materials and methods

We prospectively enrolled 14 patients with CVFs and measured the BTP in venous blood samples from the paraspinal veins near the CVF and compared those levels with those in the peripheral blood. Myelograms used initially to identify t

SUBMITTER: Mark IT 

PROVIDER: S-EPMC11878952 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature