Quantitative Susceptibility Mapping with Source Separation in Normal Brain Development of Newborns.

ABSTRACT:

Background and purpose

Quantitative susceptibility mapping is an emerging method for characterizing tissue composition and studying myelination and iron deposition. However, accurate assessment of myelin and iron content in the neonate brain using this method is challenging because these 2 susceptibility sources of opposite signs (myelin, negative; iron, positive) occupy the same voxel, with minimal and comparable content in both sources. In this study, susceptibilities were measured in the healthy neonate brain using susceptibility source separation.

Materials and methods

Sixty-nine healthy neonates without clinical indications were prospectively recruited for MRI. All neonates underwent gradient-echo imaging for quantitative susceptibility mapping. Positive (paramagnetic)

SUBMITTER: Jang M 

PROVIDER: S-EPMC11878958 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature