Imaging and Anesthesia Protocol Optimization in Sedated Clinical Resting-State fMRI.

ABSTRACT:

Background and purpose

The quality of resting-state fMRI (rs-fMRI) under anesthesia is variable and there are no guidelines on optimal image acquisition or anesthesia protocol. We aim to identify the factors that may lead to compromised clinical rs-fMRI under anesthesia.

Materials and methods

In this cross-sectional study, we analyzed clinical rs-fMRI data acquired under anesthesia from 2009-2023 at Massachusetts General Hospital. Independent component analysis-driven resting-state networks (RSNs) of each patient were evaluated qualitatively and quantitatively and grouped as robust or weak. Overall networks were evaluated by using the qualitative method, and motor and language networks were evaluated by using the quantitative method. RSN robustness was analyzed in 4 outcome

SUBMITTER: Hassanzadeh E 

PROVIDER: S-EPMC11878968 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature