Advancing systemic toxicity risk assessment: Evaluation of a NAM-based toolbox approach.

ABSTRACT: For many years, a method that allowed systemic toxicity safety assessments to be conducted without generating new animal test data, seemed out of reach. However, several different research groups and regulatory authorities are beginning to use a variety of in silico, in chemico, and in vitro techniques to inform safety decisions. To manage this transition to animal-free safety assessments responsibly, it is important to ensure that the level of protection offered by a safety assessment based on new approach methodologies (NAMs), is at least as high as that provided by a safety assessment based on traditional animal studies. To this end, we have developed an evaluation strategy to assess both the level of protection and the utility offered by a NAM-based systemic safety "toolbox." The toolb

SUBMITTER: Cable S 

PROVIDER: S-EPMC11879040 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature