IgA class-switched CD27-CD21+ B cells in IgA nephropathy.

ABSTRACT:

Background

Immunoglobulin A nephropathy (IgAN) is characterized by the production of galactose-deficient IgA1 (GdIgA1) antibodies. As the source of pathogenic antibodies, B cells are central to IgAN pathogenesis, but the B cell activation pathways as well as the potential B cell source of dysregulated IgA secretion remain unknown.

Methods

We carried out flow cytometry analysis of peripheral blood B cells in patients with IgAN and control subjects with a focus on IgA-expressing B cells to uncover the pathways of B cell activation in IgAN and how these could give rise to pathogenic GdIgA1 antibodies.

Results

In addition to global changes in the B cell landscape-expansion of naïve and reduction in memory B cells-IgAN patients present with an increased frequency of IgA-ex

SUBMITTER: Popova A 

PROVIDER: S-EPMC11879059 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature