Homologous recombination shapes the architecture and evolution of bacterial genomes.

ABSTRACT: Homologous recombination is a key evolutionary force that varies considerably across bacterial species. However, how the landscape of homologous recombination varies across genes and within individual genomes has only been studied in a few species. Here, we used Approximate Bayesian Computation to estimate the recombination rate along the genomes of 145 bacterial species. Our results show that homologous recombination varies greatly along bacterial genomes and shapes many aspects of genome architecture and evolution. The genomic landscape of recombination presents several key signatures: rates are highest near the origin of replication in most species, patterns of recombination generally appear symmetrical in both replichores (i.e. replicational halves of circular chromosomes) and most spe

SUBMITTER: Torrance EL 

PROVIDER: S-EPMC11879095 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature