NP-TCMtarget: a network pharmacology platform for exploring mechanisms of action of traditional Chinese medicine.

ABSTRACT: The biological targets of traditional Chinese medicine (TCM) are the core effectors mediating the interaction between TCM and the human body. Identification of TCM targets is essential to elucidate the chemical basis and mechanisms of TCM for treating diseases. Given the chemical complexity of TCM, both in silico high-throughput compound-target interaction predicting models and biological profile-based methods have been commonly applied for identifying TCM targets based on the structural information of TCM chemical components and biological information, respectively. However, the existing methods lack the integration of TCM chemical and biological information, resulting in difficulty in the systematic discovery of TCM action pathways. To solve this problem, we propose a novel target identi

SUBMITTER: Wang A 

PROVIDER: S-EPMC11879102 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature