Quantitative evaluation of multiple treatment regimens for treatment-resistant depression.

ABSTRACT:

Objective

This study aims to quantitatively evaluate the efficacy and safety of various treatment regimens for treatment-resistant depression (TRD) across oral, intravenous, and intranasal routes to inform clinical guidelines.

Methods

A systematic review identified randomized controlled trials on TRD, with efficacy measured by changes in the Montgomery-Åsberg Depression Rating Scale (MADRS). We developed pharmacodynamic and covariate models for different administration routes, using Monte Carlo simulations to estimate efficacy distribution. Dropout and adverse event-related dropout rates were analyzed via single-arm meta-analysis.

Results

Involving 22 studies with 56 treatment arms and 3059 patients, our findings suggest combination therapies outperform monotherapy, a

SUBMITTER: Feng Y 

PROVIDER: S-EPMC11879141 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature