Mucosal and Transmural Healing and Long-term Outcomes in Crohn's Disease.

ABSTRACT:

Background

Healing in Crohn's disease is complex and difficult to measure due to incongruencies between clinical symptoms and disease states. Mucosal healing (MH) and transmural healing (TH) are increasingly used to measure clinical improvement in Crohn's disease, but definitions of MH and TH can vary across studies, and their relationship to long-term outcomes is not clear. To address this knowledge gap, we performed a systematic literature review (SLR) to examine studies measuring MH and TH in Crohn's disease.

Methods

Database records from 2012 to 2022 were searched for real-world evidence and interventional studies that reported the association of MH or TH with clinical, economic, or quality of life outcomes of adult patients with Crohn's disease.

Results

A total o

SUBMITTER: Sands BE 

PROVIDER: S-EPMC11879194 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature