In vitro susceptibility of 147 international clinical Mycobacterium abscessus isolates to epetraborole and comparators by broth microdilution.

ABSTRACT:

Background

Mycobacterium abscessus is a highly drug-resistant non-tuberculous mycobacterium (NTM) for which treatment is limited by the lack of active oral antimycobacterials and frequent adverse reactions. Epetraborole is a novel oral, boron-containing antimicrobial that inhibits bacterial leucyl-tRNA synthetase, an essential enzyme in protein synthesis, and has been shown to have anti-M. abscessus activity in preclinical studies.

Objectives

To determine epetraborole MIC distribution for 147 recent M. abscessus isolates via broth microdilution.

Methods

M. abscessus isolates collected in 2021 from the USA (n = 122) from pulmonary sources and during 2019-22 predominantly from Europe (n = 25) from pulmonary and extrapulmonary sources had MICs determined by broth microdi

SUBMITTER: Nguyen MH 

PROVIDER: S-EPMC11879195 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature