Microvascular resistance reserve in relation to total and vessel-specific atherosclerotic burden.

ABSTRACT:

Aims

The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic burden and microvascular resistance reserve (MRR).

Methods and results

In this post hoc analysis of the PACIFIC 1 trial, symptomatic patients without prior coronary artery disease (CAD) underwent [15O]H2O positron emission tomography, coronary computed tomography angiography (CCTA), and invasive fractional flow reserve (FFR). MRR was assessed across all three coronary branches, utilizing PET-derived coronary flow reserve and invasive FFR measurements. CCTA was used to assess patient and vessel-specific plaque volumes. Percentage atheroma volume (PAV) was define

SUBMITTER: Hoshino M 

PROVIDER: S-EPMC11879247 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature