Photothermally controlled ICG@ZIF-8/PLGA coating to modify the degradation behavior and biocompatibility of Zn-Li alloy for bone implants.

ABSTRACT: Biodegradable Zn alloy has recently gained attention for use in bone implants considering its biodegradability, attractive mechanical properties and bioactivity. However, excessive corrosion of Zn alloy at the early stage of implantation may cause severe cytotoxicity, resulting in insufficient osseointegration, which hinders the clinical use of Zn alloy. In this study, we designed a photothermally controlled degradative hybrid coating as a corrosion-protective barrier with the intention of preventing Zn ion burst release during the early stages of implantation and regaining the alloy's corrosion advantage later on. The coating consists of zeolite imidazole skeleton-encapsulated indocyanine green core-shell-structured nanoparticles and polylactic coglycolic acid (ICG@ZIF-8/PLGA) on pristine

SUBMITTER: Zhang T 

PROVIDER: S-EPMC11879299 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature