Hydroxychloroquine levels in pregnancy and materno-fetal outcomes in systemic lupus erythematosus patients.

ABSTRACT:

Objectives

Data about hydroxychloroquine (HCQ) levels during pregnancy are sparse. We assessed HCQ whole-blood levels at first trimester of pregnancy as a potential predictor of maternal and obstetric/fetal outcomes in patients with systemic lupus erythematosus (SLE).

Methods

We included pregnant SLE patients enrolled in the prospective GR2 study receiving HCQ, with at least one available first-trimester whole-blood HCQ assay. We evaluated several cut-offs for HCQ whole-blood levels, including ≤200 ng/ml for severe non-adherence. Primary outcomes were maternal flares during the second and third trimesters of pregnancy, and adverse pregnancy outcomes (APOs: fetal/neonatal death, placental insufficiency with preterm delivery, and small-for-gestational-age neonates).

Results

SUBMITTER: Alle G 

PROVIDER: S-EPMC11879311 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature