Prospective assessment of glucocorticoid toxicity in rheumatology practice: a focus on the glucocorticoid toxicity index.

ABSTRACT:

Objective

The glucocorticoid toxicity index (GTI) is developed to measure glucocorticoid (GC)-related morbidity over time. This study aimed to assess GC-toxicity in patients at a rheumatology outpatient clinic by using the GTI and to identify the factors that interfere with the GTI.

Methods

This prospective study included patients with inflammatory arthritis (IA), connective tissue disease and vasculitis who were newly prescribed GC-treatment (GC-naive) or have been still on GC-treatment for ≤2 years (GC-experienced). Patient demographics and disease characteristics, aggregate improvement score (GTI-AIS), cumulative worsening score (GTI-CWS) and cumulative GC-doses were recorded at baseline, 3rd month and 6th month. Generalized estimating equations (GEE) were used to evaluat

SUBMITTER: Bahap-Kara M 

PROVIDER: S-EPMC11879322 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature