Responsiveness and sensitivity of PROMs to change in disease activity status in early and established rheumatoid arthritis.

ABSTRACT:

Objectives

To determine whether patient-reported outcome measures (PROMs) capturing activity limitations, health impact, pain, fatigue and work ability are responsive and sensitive to changes in disease activity status in patients with early and established RA.

Methods

All early RA patients (n = 557) from the tREACH trial and established RA patients (n = 188) from the TARA trial were included. Both studies were multicentre, single-blinded trials with a treat-to-target management approach. The following PROMs were studied: HAQ Disability Index (HAQ-DI), morning stiffness severity, EQ-5D, general health, 36-item short form (SF-36), joint pain, fatigue and productivity loss. Mean changes in PROMs between two consecutive visits were compared with changes in disease activity stat

SUBMITTER: Looijen AEM 

PROVIDER: S-EPMC11879326 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature