A computational study on the influence of antegrade accessory pathway location on the 12-lead electrocardiogram in Wolff-Parkinson-White syndrome.

ABSTRACT:

Aims

Wolff-Parkinson-White (WPW) syndrome is a cardiovascular disease characterized by abnormal atrioventricular conduction facilitated by accessory pathways (APs). Invasive catheter ablation of the AP represents the primary treatment modality. Accurate localization of APs is crucial for successful ablation outcomes, but current diagnostic algorithms based on the 12-lead electrocardiogram (ECG) often struggle with precise determination of AP locations. In order to gain insight into the mechanisms underlying localization failures observed in current diagnostic algorithms, we employ a virtual cardiac model to elucidate the relationship between AP location and ECG morphology.

Methods and results

We first introduce a cardiac model of electrophysiology that was specifically tailo

SUBMITTER: Gillette K 

PROVIDER: S-EPMC11879338 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature