Different intestinal ecological niches drive the divergent evolution of probiotics in the gut.

ABSTRACT: Previously, we described the divergent evolution of probiotics in the gut, which potentially compromises their health-promoting effects. Here, we employed a spatiotemporal multiomic approach to explore the distribution and evolutionary trends of the probiotic Lactiplantibacillus plantarum HNU082 (Lp082) in specific-pathogen-free and monocolonized mouse models. Initially, after establishing the inherent differences in the gut microbiota between the small and large intestines, we observed that the small intestine served as the main site for Lp082 survival and colonization. Subsequently, we discovered that the small intestine was the sole site where Lp082 exhibited divergent evolution. Moreover, our research indicated that Lp082 had a more substantial impact on the small-intestinal mic

SUBMITTER: Han Z 

PROVIDER: S-EPMC11879351 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature