Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients.

ABSTRACT:

Objectives

Rapid diagnosis and intervention are critical for sepsis patient outcomes. However, diagnosis is challenging because of a heterogenic patient group as well as sometimes vague symptoms when the patient presents at the emergency department. Mucosal-associated invariant T (MAIT) cells are rapid responders to infection, but their role and characteristics in the early course of sepsis remain unknown. Here, we evaluate the early MAIT cell characteristics in the blood of patients triggering a clinical sepsis alert system at the emergency department.

Methods

Peripheral blood mononuclear cells were isolated from freshly drawn blood and immediately stained. MAIT cell phenotyping analyses were conducted using multiparameter flow cytometry. All analyses were completed prior t

SUBMITTER: Emgard J 

PROVIDER: S-EPMC11879382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature