MRI identifies disrupted cerebral development in medulloblastoma patients.

ABSTRACT: Cognitive decline in survivors of medulloblastoma is commonly attributed to radiation- and chemotherapy-induced brain microstructural alterations. Factors preceding this adjuvant therapy, such as disrupted brain development or resection surgery, may affect brain microstructure but have not been thoroughly explored in medulloblastoma. The aim of this study was to assess cortical thickness and microstructural integrity of the cerebrum prior to adjuvant therapy in medulloblastoma patients. Cross-sectional image data were acquired of medulloblastoma patients (n = 30) after surgery but before adjuvant therapy and compared with data from healthy controls (n = 35) matched for age range (12-22 years). Biomarkers of microstructural integrity include fractional anisotropy, mean diffusi

SUBMITTER: Bag AK 

PROVIDER: S-EPMC11879392 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature