Inter-organelle communication dynamically orchestrates juvenile hormone biosynthesis and female reproduction.

ABSTRACT: Inter-organelle communication coordinates cellular homeostasis and function. Juvenile hormone (JH) is produced in the corpora allata (CA) and acts as a gonadotrophic hormone in most insects. Using transcriptomic, biochemical, molecular, and genetic analyses, here we investigated the underlying mechanism of how inter-organelle communication dynamically orchestrates JH biosynthesis and female reproduction in the American cockroach, Periplaneta americana. The extracellular stimuli insulin and allatostatin act through their membrane receptors and antagonistically regulate RyR-mediated Ca²⁺ release from the endoplasmic reticulum in CA cells. Ca²⁺-activated CaMKII stimulates energy metabolism in the mitochondria partially via SLC25A6, and induces the expressio

SUBMITTER: Zhu S 

PROVIDER: S-EPMC11879407 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature