Longitudinal Associations Between Self-reported Schizotypy Dimensions and White Matter Integrity Development During Adolescence.

ABSTRACT:

Background

Alterations of white matter microstructure have been reported in the psychosis spectrum. However, the development of these alterations during preclinical stages remains poorly understood. The framework proposed by schizotypy research as the personality base for liability to develop psychosis spectrum disorders offers 3 interconnected dimensions thought to impact neurodevelopment, affording an opportunity to investigate premorbid risk.

Design

In this study, 102 typically developing individuals aged between 12 and 20 y.o. at baseline were scanned longitudinally between 1 and 4 times, and schizotypy was assessed at each visit. Ten white matter tracts were reconstructed using TRACULA, and mixed model regression was used to characterize age-related changes in main diff

SUBMITTER: Derome M 

PROVIDER: S-EPMC11879505 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature