Invasive Pneumococcal Disease and Impact of 7- and 13-Valent Pneumococcal Conjugate Vaccines in Singapore Children Over 24 Years.

ABSTRACT:

Background

Data on burden of invasive pneumococcal disease (IPD) are lacking from Southeast Asia. With the introduction of higher-valency pneumococcal conjugate vaccines (PCVs), we aim to assess the impact of PCV introduction into Singapore's National Childhood Immunisation Schedule (NCIS) on IPD burden and serotype replacement.

Methods

Using IPD surveillance data from a single center, we compared the incidence of IPD in children aged <17 years before and after introduction of the PCV into the NCIS (2000-2009, period 1; 2010-2023, period 2).

Results

The overall incidence of IPD from 2000 to 2023 was 3.9 per 100 000 children. The decline in IPD incidence between periods 1 and 2 was greatest in children aged ≤2 years (13.3 to 4.7/100 000 children; incidence rate ratio 0

SUBMITTER: Li J 

PROVIDER: S-EPMC11879520 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature