Cortical Morphology Alterations Mediate the Relationship Between Glymphatic System Function and the Severity of Asthenopia.

ABSTRACT: Objectives: This study is aimed at assessing glymphatic function by diffusion tensor image analysis along the perivascular space (DTI-ALPS) and its associations with cortical morphological changes and severity of accommodative asthenopia (AA). Methods: We prospectively enrolled 50 patients with AA and 47 healthy controls (HCs). All participants underwent diffusion tensor imaging (DTI) and T1-weighted imaging and completed the asthenopia survey scale (ASS). Differences in brain morphometry and the analysis along the perivascular space (ALPS) index between the two groups were compared. The correlation and mediation analyses were conducted to explore the relationships between them. Results: Compared to HCs, patients with AA exhibited significantly increased sulcal depth i

SUBMITTER: Chen Y 

PROVIDER: S-EPMC11879604 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature