Is late-life vulnerability to cardiovascular disease risk associated with longitudinal tau accumulation in older adults with mild cognitive impairment?

ABSTRACT:

Background

Older females have higher Alzheimer's Disease (AD) risk and tau burden, especially in early disease stages, compared to males. Overlapping cardiovascular disease (CVD) and dementia risk factors, like the apolipoprotein (APOE)-ε4 allele, show mixed sex-specific results. We previously found that late-life CVD risk related more strongly to tau at a single timepoint in cognitively normal, older female APOE-ε4 carriers than in males.

Objectives

Do composite and component CVD risk factors explain sex differences in tau accumulation in older adults with mild cognitive impairment (MCI) and underlying amyloid-beta (Aβ) pathology?

Design

Longitudinal analysis in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.

Setting

ADNI is a multi-site longitu

SUBMITTER: Dratva MA 

PROVIDER: S-EPMC11879684 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature