Understanding the link between ALDH2 genotypes and diabetes.

ABSTRACT:

Introduction

The association between aldehyde dehydrogenase-2 (ALDH2) rs671 and diabetes remains controversial, with uncertainty about whether alcohol consumption or other factors mediate or modify this relationship. This study aimed to examine the ALDH2-diabetes association using standardized clinical criteria while systematically investigating potential confounding, mediating, and interacting factors in a community-based cohort.

Method

We analyzed baseline data from 4,535 participants in the China Cardiometabolic Disease and Cancer Cohort Study (4C study). Diabetes was diagnosed based on standardized clinical criteria, including fasting plasma glucose, 2-h postprandial glucose, glycosylated hemoglobin A1c (HbA1c), or documented prior diagnosis. We evaluated the association

SUBMITTER: Peng M 

PROVIDER: S-EPMC11879816 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature