Sex-specific prognostic utility of the sarcopenia index in all-cause mortality risk for patients with heart failure.

ABSTRACT:

Background

The sarcopenia index (SI), derived from serum creatinine and cystatin C levels, has emerged as a novel and accessible biomarker for predicting clinical outcomes. However, its sex-specific prognostic utility in heart failure (HF) remains poorly understood. This study aimed to investigate the association between SI and all-cause mortality in HF, with a focus on sex-specific differences.

Methods

A retrospective cohort of 753 patients (median age: 69 years; 61% male) diagnosed with HF from a tertiary hospital in China was analyzed. Cox regression models and Kaplan-Meier survival analyses were utilized to evaluate the relationship between SI and all-cause mortality. Stratified analyses based on sex were performed, and the incremental predictive value of SI was assessed

SUBMITTER: Li M 

PROVIDER: S-EPMC11879831 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature