Evaluating the Cost-Effectiveness of Antenatal Screening for Major Structural Anomalies During the First Trimester of Pregnancy: A Decision Model.

ABSTRACT:

Objective

To assess the cost-effectiveness of modifying current antenatal screening by adding first trimester structural anomaly screening to standard of care second trimester anomaly screening.

Design

Health economic decision model.

Setting

National Health Service (NHS) in England and Wales.

Population

Pregnant women attending for first trimester antenatal screening.

Methods

The decision model estimated pregnancy outcomes (maternal and foetal) and 20-year costs for current screening practice and for a policy adding a protocol screening for eight major structural anomalies to the current first trimester ultrasound scan. Event probabilities, costs, and outcomes for the model were informed by meta-analyses, published literature, and expert opinion.

Main

SUBMITTER: Campbell HE 

PROVIDER: S-EPMC11879910 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature