Association between the lactate-to-albumin ratio (LAR) index and risk of acute kidney injury in critically ill patients with sepsis: analysis of the MIMIC-IV database.

ABSTRACT:

Background

Lactate-to-albumin ratio (LAR) is an emergency predictive indicator of sepsis-related mortality. An elevated LAR is associated with poor outcomes in critically ill patients. However, its predictive value for acute kidney injury (AKI) in patients with sepsis remains unclear. Therefore, this study aimed to investigate the relationship between LAR and AKI in patients with sepsis.

Methods

The study population was derived from the Medical Information Mart for Intensive Care-IV (2.0) database and stratified into quartiles based on the LAR. The primary endpoint was the occurrence of AKI. The secondary endpoints were the use of renal replacement therapy (RRT) and in-hospital mortality. Kaplan-Meier survival analysis and Cox proportional hazards models were used to assess

SUBMITTER: Hua Y 

PROVIDER: S-EPMC11879934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature