Dietary phytochemical indole-3-carbinol regulates metabolic reprogramming in mouse prostate tissue.

ABSTRACT:

Purpose

Indole-3-carbinol (I3C) is shown to possess multiple pharmacological activities such as anti-inflammatory, antimicrobial, antioxidant, antiviral, and anti-cancer activities. It is widely accepted as modulator of multiple signaling pathways particularly those related to cell cycle, cell growth and division, angiogenesis, apoptosis and immunity. We explored the metabolic reprogramming based on treatment with I3C in mice prostate tissue.

Methods

In this study we utilized Pten knockout (KO)-induced prostate tumorigenesis mouse model to examine mechanism of action of I3C via metabolic rewiring. Phosphatase and tensin homolog deleted on chromosome 10 (Pten), a tumor suppressor gene is frequently found to be mutated or deleted in prostate cancer. Untargeted metabolomics was

SUBMITTER: Peter RM 

PROVIDER: S-EPMC11880055 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature