The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility.

ABSTRACT: Recently, infertility has emerged as a significant and prevalent public health concern warranting considerable attention. Apoptosis, recognized as programmed cell death, constitutes a crucial process essential for the maintenance of normal spermatogenesis. Multiple investigations have illustrated that the dysregulated apoptosis of reproductive cells, encompassing spermatogonial stem cells, Sertoli cells, and Leydig cells, serves as a causative factor in male infertility. MicroRNAs represent a class of small RNA molecules that exert negative regulatory control over gene expression using direct interaction with messenger RNA transcripts. Previous studies have established that aberrant expression of miRNAs induces apoptosis in reproductive tissues, correlating with reproductive dysfunctions a

SUBMITTER: Yu P 

PROVIDER: S-EPMC11880093 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature