Behcet's disease: incidence, prevalence, and real-word data on the use of biologic agents in Japan.

ABSTRACT:

Background

Behçet's disease (BD) is an autoinflammatory disease that can affect multiple organs, including the gastrointestinal tract. Conventional management comprises anti-inflammatory drugs such as glucocorticoids (GCs) and/or immunomodulators that alleviate symptoms. The introduction of biological agents that target tumor necrosis factor α (TNF-α) has improved disease management. The goal of this work was to analyze the current prevalence and incidence of total BD and gastrointestinal Behçet's disease (GIBD) in Japan, and examine treatment trends, especially regarding the use of TNF-α inhibitors (TNFαi).

Methods

We performed a retrospective descriptive observational study in which BD and GIBD demographic trends, medical treatment patterns, and reported adverse events (AE

SUBMITTER: Hisamatsu T 

PROVIDER: S-EPMC11880103 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature